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免疫性血小板减少症相关性疲劳
Immune Thrombocytopenia-Related Fatigue

DOI: 10.12677/ACM.2020.109326, PP. 2162-2168

Keywords: 免疫性血小板减少症,疲劳,生活质量
Immune Thrombocytopenia
, Fatigue, Quality of Life

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Abstract:

疲劳是与健康相关生活质量(HRQoL)的重要方面,也是慢性病常见的表现,严重影响患者生活质量的同时,可能导致严重的社会经济后果。成人和儿童免疫性血小板减少症(Immune thrombocytopenia, ITP)患者中大部分存在疲劳,经验证的、可靠的疲劳量表已用于ITP评估,这有助于对其发病机制和干预效果进行调查研究。有效的ITP治疗可以改善疲劳,但临床医生在评估ITP疾病负担时应考虑干预疲劳的策略,可借鉴和参考其他慢性病相关性疲劳的治疗方法和策略,ITP相关疲劳也可从中医药治疗中获益。
Fatigue is an important aspect of health-related quality of life (HRQoL). It is also a common manifestation of chronic diseases, which seriously affects the quality of life of patients and can have significant socioeconomic consequences. Most of both adults and children with immune thrombocytopenia (ITP) suffer from fatigue. Validated, reliable fatigue scale has been developed for the use in ITP. These will facilitate future investigation of its pathogenesis and the effectiveness of intervention. Although effective ITP treatment can improve fatigue, clinicians should consider strategies for intervention fatigue when assessing the burden of ITP disease. Clinicians can learn from other chronic disease related fatigue treatment methods and strategies, ITP related fatigue can also benefit from the treatment of Traditional Chinese Medicine.

References

[1]  Liu, X.G., Bai, X.C., Chen, F.P., et al. (2018) Chinese Guidelines for Treatment of Adult Primary Immune Thrombocytopenia. International Journal of Hematology, 107, 615-623.
https://doi.org/10.1007/s12185-018-2445-z
[2]  Efficace, F., Mandelli, F., Fazi, P., et al. (2016) Health-Related Quality of Life and Burden of Fatigue in Patients with Primary Immune Thrombocytopenia by Phase of Disease. American Journal of Hematology, 91, 995-1001.
https://doi.org/10.1002/ajh.24463
[3]  Yang, R., Yao, H., Lin, L., et al. (2019) Health-Related Quality of Life and Burden of Fatigue in Chinese Patients with Immune Thrombocytopenia: A Cross-Sectional Study. Indian Journal of Hematology and Blood Transfusion, 36, 1-8.
https://doi.org/10.1007/s12288-019-01124-7
[4]  李洋, 吕明恩, 郝亚停, 等. 成人原发免疫性血小板减少症患者疲劳症状及影响因素分析[J]. 中华血液学杂志, 2017, 38(5): 384-389.
[5]  Grace, R.F., Klaassen, R.J., Shimano, K.A., et al. (2020) Fatigue in Children and Adolescents with Immune Thrombocytopenia. British Journal of Haematology.
https://doi.org/10.1111/bjh.16751
[6]  Matzdorff, A., Meyer, O., Ostermann, H., et al. (2018) Immune Thrombocytopenia-Current Diagnostics and Therapy: Recommendations of a Joint Working Group of DGHO, ?GHO, SGH, GPOH, and DGTI. Oncology Research and Treatment, 41, 1-30.
https://doi.org/10.1159/000492187
[7]  杨冉, 林琳, 沈群. 原发免疫性血小板减少症相关性疲劳的研究进展[J]. 中国实用内科杂志, 2020, 40(3): 252-255.
[8]  Neunert, C.E. and Cooper, N. (2018) Evidence-Based Management of Immune Thrombocytopenia: ASH Guideline Update. Hematology, ASH Education Program, 30, 568-575.
https://doi.org/10.1182/asheducation-2018.1.568
[9]  Klaassen, R.J., Blanchette, V.S., Barnard, D., et al. (2007) Validity, Reliability, and Responsiveness of a New Measure of Health-Related Quality of Life in Children with Immune Thrombocytopenic Purpura: The Kids’ ITP Tools. The Journal of Pediatrics, 150, 510-515.
https://doi.org/10.1016/j.jpeds.2007.01.037
[10]  王网娣. ITP-PAQ特异性评价原发免疫性血小板减少症患者的生活质量[D]: [硕士学位论文]. 济南: 山东大学, 2018.
[11]  Klaassen, R.J., Blanchette, V., Burke, T.A., et al. (2013) Quality of Life in Childhood Immune Thrombocytopenia: International Validation of the Kids’ ITP Tools. Pediatric Blood & Cancer, 60, 95-100.
https://doi.org/10.1002/pbc.24257
[12]  杨晓东. 原发性免疫性血小板减少症治疗后生存质量调查[J]. 血栓与止血学, 2016, 22(1): 57-60.
[13]  Trotter, P. and Hill, Q.A. (2018) Immune Thrombocytopenia: Improving Quality of Life and Patient Outcomes. Patient Related Outcome Measures, 9, 369-384.
https://doi.org/10.2147/PROM.S140932
[14]  Signorovitch, J., Brainsky, A. and Grotzinger, K.M. (2011) Validation of the FACIT-Fatigue Subscale, Selected Items from FACT-Thrombocytopenia, and the SF-36v2 in Patients with Chronic Immune Thrombocytopenia. Quality of Life Research, 20, 1737-1744.
https://doi.org/10.1007/s11136-011-9912-9
[15]  Ni, J., Zeng, Q.S., Chen, Y., et al. (2015) Analysis of Epidemiological and Clinic Features of 1160 Adult Patients with Immune Thrombocytopenia. Journal of Medical Imaging and Health Informatics, 5, 800-806.
https://doi.org/10.1166/jmihi.2015.1460
[16]  Berti, D., Moons, P., Dobbels, F., et al. (2008) Impact of Corticosteroid-Related Symptoms in Patients with Immune Thrombocytopenic Purpura: Results of a Survey of 985 Patients. Clinical Therapeutics, 30, 1540-1552.
https://doi.org/10.1016/j.clinthera.2008.08.005
[17]  Newton, J.L., Reese, J.A., Watson, S.I., et al. (2011) Fatigue in Adult Patients with Primary Immune Thrombocytopenia. European Journal of Haematology, 86, 420-429.
https://doi.org/10.1111/j.1600-0609.2011.01587.x
[18]  George, J.N., Mathias, S.D., Go, R.S., et al. (2009) Improved Quality of Life for Romiplostim Treated Patients with Chronic Immune Thrombocytopenic Purpura: Results from Two Randomized, Placebo-Controlled Trials. British Journal of Haematology, 144, 409-415.
https://doi.org/10.1111/j.1365-2141.2008.07464.x
[19]  Mitchell, E., Frith, J. and Newton, J. (2019) Fatigue and Cognitive Impairment in Immune Thrombocytopenic Purpura Remain Stable over Time: Short Report from a Longitudinal Study. British Journal of Haematology, 186, 777-781.
https://doi.org/10.1111/bjh.15993
[20]  Bussel, J.B., Kruse, A., Kruse, C., et al. (2019) The Burden of Disease and IMPACT of Immune Thrombocytopenia (ITP) on Patients: Results from an ITP Survey. Blood, 134, 1076.
https://doi.org/10.1182/blood-2019-131351
[21]  Kruse, A., Kruse, C., Potthast, N., et al. (2019) Mental Health and Treatment in Patients with Immune Thrombocytopenia (ITP); Data from the Platelet Disorder Support Association (PDSA) Patient Registry. Blood, 134, 2362.
https://doi.org/10.1182/blood-2019-122278
[22]  Kruse, C., Kruse, A., Watson, S., et al. (2018) Patients with Immune Thrombocytopenia (ITP) Frequently Experience Severe Fatigue But Is It Under-Recognized by Physicians: Results from the ITP World Impact Survey (I-WISh). Blood, 132, 2273.
https://doi.org/10.1182/blood-2018-99-112378
[23]  Sarpatwari, A., Watson, S., Erqou, S., et al. (2020) Health-Related Lifestyle in Adults and Children with Primary Immune Thrombocytopenia (ITP). British Journal of Haematology, 151, 189-191.
https://doi.org/10.1111/j.1365-2141.2010.08322.x
[24]  Giordano, P., Lassandro, G., di Meo, N.A., et al. (2019) A Narrative Approach to Describe QoL in Children with Chronic ITP. Frontiers in Pediatrics, 7, 344.
https://doi.org/10.3389/fped.2019.00163
[25]  Wang, L., Xu, L., Hao, H., et al. (2020) First Line Treatment of Adult Patients with Primary Immune Thrombocytopenia: A Real-World Study. Platelets, 31, 55-61.
https://doi.org/10.1080/09537104.2019.1572875
[26]  Grace, R.F. and Neunert, C. (2016) Second-Line Therapies in Immune Thrombocytopenia. Hematology, ASH Education Program, 2016, 698-706.
https://doi.org/10.1182/asheducation-2016.1.698
[27]  Snyder, C.F., Mathias, S.D., Cella, D., et al. (2008) Health-Related Quality of Life of Immune Thrombocytopenic Purpura Patients: Results from a Web-Based Survey. Current Medical Research and Opinion, 24, 2767-1776.
https://doi.org/10.1185/03007990802377461
[28]  杨冉, 林琳, 季建敏, 等. 中文版慢性病治疗功能评估–疲劳量表在ITP患者中的应用及疲劳影响因素分析[J]. 临床血液学杂志, 2019, 32(3): 213-217.
[29]  Zhou, Z., Yang, L., Chen, Z., et al. (2007) Health-Related Quality of Life Measured by the Short Form 36 in Immune Thrombocytopenic Purpura: A Cross-Sectional Survey in China. European Journal of Haematology, 78, 518-523.
https://doi.org/10.1111/j.1600-0609.2007.00844.x
[30]  Terrell, D.R., Reese, J.A., Branesky, D., et al. (2016) Depression in Adult Patients with Primary Immune Thrombocytopenia. American Journal of Hematology, 91, e462-e463.
https://doi.org/10.1002/ajh.24484
[31]  Arnold, D.M., Heddle, N.M., Carruthers, J., et al. (2012) A Pilot Randomized Trial of Adjuvant Rituximab or Placebo for Nonsplenectomized Patients with Immune Thrombocytopenia. Blood, 119, 1356-1362.
https://doi.org/10.1182/blood-2011-08-374777
[32]  Janssens, A., Tarantino, M.D., Bird, R., et al. (2011) Final Results from an International, Multi-Center, Single-Arm Study Evaluating the Safety and Efficacy of Romiplostim in Adults with Primary Immune Thrombocytopenia (ITP). Blood, 118, 3279.
https://doi.org/10.1182/blood.V118.21.3279.3279
[33]  Kuter, D.J., Bussel, J.B., Newland, A., et al. (2013) Long-Term Treatment with Romiplostim in Patients with Chronic Immune Thrombocytopenia: Safety and Efficacy. British Journal of Haematology, 161, 411-423.
https://doi.org/10.1111/bjh.12260
[34]  Wong, R.S.M., Saleh, M.N., Khelif, A., et al. (2017) Safety and Efficacy of Long-Term Treatment of Chronic/Persistent ITP with Eltrombopag: Final Results of the EXTEND Study. Blood, 130, 2527-2536.
https://doi.org/10.1182/blood-2017-04-748707
[35]  Shaffer, C.S., Haq, N. and Bussel, J.B. (2012) Survey of the Side Effects of ITP Therapies. Blood, 120, 3327.
https://doi.org/10.1182/blood.V120.21.3327.3327
[36]  Newland, A., Lee, E.J., McDonald, V., et al. (2018) Fostamatinib for Persistent/Chronic Adult Immune Thrombocytopenia. Immunotherapy, 10, 9-25.
https://doi.org/10.2217/imt-2017-0097
[37]  Norheim, K.B., Jonsson, G. and Omdal, R. (2011) Biological Mechanisms of Chronic Fatigue. Rheumatology (Oxford), 50, 1009-1018.
https://doi.org/10.1093/rheumatology/keq454
[38]  Morris, G., Berk, M., Walder, K., et al. (2015) Central Pathways Causing Fatigue in Neuro-Inflammatory and Autoimmune Illnesses. BMC Medicine, 13, 28.
https://doi.org/10.1186/s12916-014-0259-2
[39]  Morris, G., Berk, M., Galecki, P., et al. (2016) The Neuro-Immune Pathophysiology of Central and Peripheral Fatigue in Systemic Immune-Inflammatory and Neuro-Immune Diseases. Molecular Neurobiology, 53, 1195-1219.
https://doi.org/10.1007/s12035-015-9090-9
[40]  Silverman, M.N., Heim, C.M., Nater, U.M., et al. (2010) Neuroendocrine and Immune Contributors to Fatigue. PM R, 2, 338-346.
https://doi.org/10.1016/j.pmrj.2010.04.008
[41]  王明镜, 许勇钢, 丁晓庆, 等. 免疫性血小板减少症患者促炎因子与抑炎因子分泌失衡[J]. 中国实验血液学杂志, 2018, 26(2): 522-527.
[42]  周正菊, 张友山, 梁彩霞, 等. ITP患者外周血Th9、Th17和Treg细胞水平及IL-9、IL-17和TGF-β表达在ITP发病中的作用[J]. 中国实验血液学杂志, 2019, 27(1): 180-184.
[43]  王洪志, 朱世荣, 胡晓梅, 等. 气不摄血证免疫性血小板减少症患者血管活性物质及相关炎症因子变化与临床意义[J]. 世界科学技术-中医药现代化, 2020, 22(3): 901-906.
[44]  Audia, S., Mahevas, M., Samson, M., et al. (2017) Pathogenesis of Immune Thrombocytopenia. Autoimmunity Reviews, 16, 620-632.
https://doi.org/10.1016/j.autrev.2017.04.012
[45]  McKenzie, C.G., Guo, L., Freedman, J., et al. (2013) Cellular Immune Dysfunction in Immune Thrombocytopenia (ITP). British Journal of Haematology, 163, 10-23.
https://doi.org/10.1111/bjh.12480
[46]  Li, H.Y., Zhang, D.L., Zhang, X., et al. (2015) Interleukin-7 Is Decreased and Maybe Plays a Pro-Inflammatory Function in Primary Immune Thrombocytopenia. Platelets, 26, 243-249.
https://doi.org/10.3109/09537104.2014.903392
[47]  Thong, M.S.Y., van Noorden, C.J.F., Steindorf, K., et al. (2020) Cancer-Related Fatigue: Causes and Current Treatment Options. Current Treatment Options in Oncology, 21, 17.
https://doi.org/10.1007/s11864-020-0707-5
[48]  Mehrabani, S., Askari, G., Miraghajani, M., et al. (2019) Effect of Coenzyme Q10 Supplementation on Fatigue: A Systematic Review of Interventional Studies. Complementary Therapies in Medicine, 43, 181-187.
https://doi.org/10.1016/j.ctim.2019.01.022
[49]  Peppone, L.J., Inglis, J.E., Mustian, K.M., et al. (2019) Multicenter Randomized Controlled Trial of Omega-3 Fatty Acids versus Omega-6 Fatty Acids for the Control of Cancer-Related Fatigue among Breast Cancer Survivors. JNCI Cancer Spectrum, 3, pkz005.
https://doi.org/10.1093/jncics/pkz005
[50]  Mücke, M., Mochamat, Cuhls, H., et al. (2016) Pharmacological Treatments for Fatigue Associated with Palliative Care: Executive Summary of a Cochrane Collaboration Systematic Review. Journal of Cachexia, Sarcopenia and Muscle, 7, 23-27.
https://doi.org/10.1002/jcsm.12101
[51]  Zhou, S.S. and Jiang, J.G. (2019) Anti-Fatigue Effects of Active Ingredients from Traditional Chinese Medicine: A Review. Current Medicinal Chemistry, 26, 1833-1848.
https://doi.org/10.2174/0929867324666170414164607
[52]  赖秋媛, 谢辑文, 陈道睿, 等. 中医药治疗运动性疲劳研究[J]. 新中医, 2018, 50(9): 28-33.
[53]  张玲, 陈科, 张雅月, 等. 健脾益气摄血方治疗免疫性血小板减少症临床疗效及其机制研究[J]. 北京中医药大学学报, 2020, 43(4): 343-352.
[54]  王珺, 张蕴, 张玲, 等. 健脾益气摄血颗粒治疗免疫性血小板减少症临床疗效观察[J]. 中华中医药杂志, 2018, 33(12): 5700-5704.
[55]  杨冉, 姚浩, 季建敏, 等. 益气养阴和血方治疗慢性原发免疫性血小板减少症的临床观察[J]. 中国中西医结合杂志, 2019, 39(3): 305-309.
[56]  王明镜, 全日城, 丁晓庆, 等. 益气摄血方治疗气不摄血证免疫性血小板减少症多中心、随机、双盲、对照研究[J]. 中国中西医结合杂志, 2020, 40(8): 929-934.

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