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糖尿病行为学异常及STZ糖尿病小鼠模型
Behavioral Abnormalities of Diabetes Mellitus and Streptozotocin-Induced Diabetic Mouse Model

DOI: 10.12677/ACM.2020.107203, PP. 1348-1352

Keywords: 糖尿病，行为，模型，链脲佐菌素
Diabetes Mellitus, Behavior, Model, Streptozotocin

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Abstract:

糖尿病发病率及病死率逐年升高，糖尿病患者可表现出行为学异常，行为学异常包括行为异常和心理异常，无论是行为异常还是心理异常均降低了糖尿病患者的生活质量、提高了医疗成本，早期识别糖尿病行为学异常可帮助患者提高生活质量、降低医疗成本。糖尿病动物模型主要包括1型糖尿病模型及2型糖尿病模型等，其中诱发性1型糖尿病模型中的链脲佐菌素诱导的糖尿病小鼠模型应用最为广泛。
Diabetes Mellitus and related morbidity and mortality are increasing at an alarming rate, and diabetic patients can show abnormalities, they include behavioral abnormalities and psychological abnormalities. Both behavioral and psychological abnormalities can reduce the quality of life of diabetic patients and increase medical costs. Early identification of diabetic abnormalities can help patients improve their quality of life and reduce medical costs. Diabetic animal models mainly include type 1 and type 2, among which streptozotocin-induced diabetic mouse model is the most widely used.

References

[1]  Kahn, C.R., et al. (2004) Joslin’s Diabetes Mellitus. Lippincott Williams & Wilkins, Philadelphia.
[2]  中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2017年版)[J]. 中华糖尿病杂志, 2018, 10(1): 4-67.
[3]  Xu, Y., et al. (2013) Prevalence and Control of Diabetes in Chinese Adults. JAMA, 310, 948-959.
https://doi.org/10.1001/jama.2013.168118
[4]  Anderson, R.J., et al. (2001) The Prevalence of Comorbid Depression in Adults with Diabetes: A Meta-Analysis. Diabetes Care, 24, 1069-1078.
https://doi.org/10.2337/diacare.24.6.1069
[5]  Iturralde, E., et al. (2019) Association of Anxiety with High-Cost Health Care Use among Individuals with Type 2 Diabetes. Diabetes Care, 42, 1669-1674.
https://doi.org/10.2337/dc18-1553
[6]  Gylfadottir, S.S., et al. (2020) Diabetic Polyneuropathy and Pain, Prevalence, and Patient Characteristics: A Cross-Sectional Questionnaire Study of 5,514 Patients with Recently Diagnosed Type 2 Diabetes. Pain, 161, 574-583.
https://doi.org/10.1097/j.pain.0000000000001744
[7]  Lindberg, L., et al. (2020) Anxiety and Depression in Children and Adolescents with Obesity: A Nationwide Study in Sweden. BMC Medicine, 18, Article No. 30.
https://doi.org/10.1186/s12916-020-1498-z
[8]  Jebeile, H., et al. (2019) Association of Pediatric Obesity Treatment, Including a Dietary Component, with Change in Depression and Anxiety: A Systematic Review and Meta-Analysis. JAMA Pediatrics, 173, e192841.
https://doi.org/10.1001/jamapediatrics.2019.2841
[9]  Lipnicki, D.M., et al. (2019) Determinants of Cognitive Performance and Decline in 20 Diverse Ethno-Regional Groups: A Cosmic Collaboration Cohort Study. PLoS Medicine, 16, e1002853.
[10]  de Groot, M., et al. (2016) Lifetime Duration of Depressive Disorders in Patients with Type 2 Diabetes. Diabetes Care, 39, 2174-2181.
https://doi.org/10.2337/dc16-1145
[11]  Yates, T., et al. (2019) Impact of Depression and Anxiety on Change to Physical Activity Following a Pragmatic Diabetes Prevention Program within Primary Care: Pooled Analysis from Two Randomized Controlled Trials. Diabetes Care, 42, 1847-1853.
https://doi.org/10.2337/dc19-0400
[12]  Dias, A., et al. (2019) Effect of a Lay Counselor Intervention on Prevention of Major Depression in Older Adults Living in Low- and Middle-Income Countries: A Randomized Clinical Trial. JAMA Psychiatry, 76, 13-20.
https://doi.org/10.1001/jamapsychiatry.2018.3048
[13]  Makino, S., Kwnimoto, K. and Muraoka, Y. (1980) Breeding of a Nonobese, Diabetic Strain of Mice. Experimental Animals, 29, 1-13.
https://doi.org/10.1538/expanim1978.29.1_1
[14]  Leiter, E.H. (1997) The NOD Mouse: A Model for Insulin-Dependent Diabetes Mellitus. Current Protocols in Immunology, 24, 15.9.1-15.9.23.
https://doi.org/10.1002/0471142735.im1509s24
[15]  Nakhooda, A.F., et al. (1976) The Spontaneously Diabetic Wistar Rat Metabolic and Morphologic Studies. Diabetes, 26, 100-112.
https://doi.org/10.2337/diab.26.2.100
[16]  Lenzen, S. (2008) The Mechanisms of Alloxan- and Streptozotocin-Induced Diabetes. Diabetologia, 51, 216-226.
https://doi.org/10.1007/s00125-007-0886-7
[17]  Bao, J., et al. (2017) Sex Differences in the Cognitive and Hippocampal Effects of Streptozotocin in an Animal Model of Sporadic AD. Frontiers in Aging Neuroscience, 9, 347.
https://doi.org/10.3389/fnagi.2017.00347
[18]  农慧, 等. STZ诱导糖尿病大鼠模型的研究[J]. 广西医科大学学报, 2010, 27(1): 69-72.
[19]  Liu, L., et al. (2017) Hypoglycemic Effect of the Polyphenols Rich Extract from Rose rugosa Thunb on High Fat Diet and STZ Induced Diabetic Rats. Journal of Ethnopharmacology, 200, 174-181.
https://doi.org/10.1016/j.jep.2017.02.022
[20]  金勇, 朱勇, 吴南翔. 实验性链脲佐菌素诱导的大小鼠糖尿病动物模型研究进展[J]. 中国比较医学杂志, 2009, 19(3): 80-82.
[21]  Zheng, C., et al. (2019) Inhibition of STAT3 in Tubular Epithelial Cells Prevents Kidney Fibrosis and Nephropathy in STZ-Induced Diabetic Mice. Cell Death & Disease, 10, 848.
https://doi.org/10.1038/s41419-019-2085-0
[22]  Tan, X., et al. (2019) Role of CCR2 in the Development of Streptozotocin-Treated Diabetic Cardiomyopathy. Diabetes, 68, 2063-2073.
https://doi.org/10.2337/db18-1231
[23]  Liang, Z., et al. (2019) Chemerin-Induced Macrophages Pyroptosis in Fetal Brain Tissue Leads to Cognitive Disorder in Offspring of Diabetic Dams. Journal of Neuroinflammation, 16, 226.
https://doi.org/10.1186/s12974-019-1573-6
[24]  Impellizzeri, D., et al. (2019) The Neuroprotective Effects of Micronized PEA (PEA-m) Formulation on Diabetic Peripheral Neuropathy in Mice. FASEB Journal, 33, 11364-11380.
https://doi.org/10.1096/fj.201900538R

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