全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

脂联素对慢性肾脏病的影响
The Effect of Adiponectin on Chronic Kidney Disease

DOI: 10.12677/ACM.2020.109312, PP. 2079-2086

Keywords: 脂联素,慢性肾脏病,治疗
Adiponectin
, Chronic Kidney Disease, Treatment

Full-Text   Cite this paper   Add to My Lib

Abstract:

脂联素具有抗动脉粥样硬化、提高肝脏和骨骼肌的胰岛素敏感性、抑制促炎细胞因子的表达以及减少血小板聚集和血栓形成等作用。研究显示脂联素与慢性肾脏病的进展息息相关,因此探讨脂联素对慢性肾脏病的影响对新治疗策略的制定至关重要。
Adiponectin has the effects of anti-atherosclerosis, increasing insulin sensitivity of the liver and skeletal muscle, inhibiting the expression of proinflammatory cytokines, and reducing platelet aggregation and thrombosis. Studies have shown that adiponectin is closely related to the progression of chronic kidney disease, so exploring the impact of adiponectin on chronic kidney disease is crucial for the development of new treatment strategies.

References

[1]  Palit, S.P., Patel, R., Jadeja, S.D., Rathwa, N., Mahajan, A., Ramachandran, A.V., Dhar, M.K., Sharma, S. and Begum, R. (2020) A Genetic Analysis Identifies a Haplotype at Adiponectin Locus: Association with Obesity and Type 2 Diabetes. Scientific Reports, 10, Article No. 2904.
[2]  Niu, M.M., Xiang, L., Liu, Y.Q., Zhao, Y.Q., Yuan, J.F., Dai, X. and Chen, H. (2017) Adiponectin Induced AMPK Impairment Mediates Insulin Resistance in Bama Mini-Pig Fed High-Fat and High-Sucrose Diet. Asian Australasian Journal of Animal Sciences, 30, 1190-1197.
https://doi.org/10.1038/s41598-020-59845-z
[3]  陈佩娜, 吴小燕, 梁姗姗, 等. 维持性血液透析患者脂联素与左室肥厚的相关性[J]. 武汉大学学报(医学版), 2019, 40(1): 116-120.
[4]  Zha, D.Q., Wu, X.Y. and Gao, P. (2017) Adiponectin and Its Receptors in Diabetic Kidney Disease: Molecular Mechanisms and Clinical Potential. Endocrinology, 158, 2022-2034.
https://doi.org/10.1210/en.2016-1765
[5]  Goto, M., Goto, A., Morita, A., et al. (2014) Low-Molecular-Weight Adiponectin and High-Molecular-Weight Adiponectin Levels in Relation to Diabetes. Obesity, 22, 401-407.
https://doi.org/10.1002/oby.20553
[6]  Kuo, I.C., Wu, P.H., Lin, H.Y.-H., Niu, S.-W., Huang, J.-C., Hung, C.-C., Chiu, Y.-W. and Chen, H.-C. (2019) The Association of Adiponectin with Metabolic Syndrome and Clinical Outcome in Patients with Non-Diabetic Chronic Kidney Disease. PLoS ONE, 14, e0220158.
https://doi.org/10.1371/journal.pone.0220158
[7]  Rhee, C.M., Nguyen, D.V., Moradi, H., Brunelli, S.M., et al. (2015) Association of Adiponectin with Body Composition and Mortality in Hemodialysis Patients. American Journal of Kidney Diseases, 66, 313-321.
https://doi.org/10.1053/j.ajkd.2015.02.325
[8]  Tsigalou, C., Chalikias, G., Kantartzi, K., et al. (2013) Differential Effect of Baseline Adiponectin on All-Cause Mortality in Hemodialysis Patients Depending on Initial Body Mass Index. Long-Term Follow-Up Data of 4.5 Years. Journal of Renal Nutrition, 23, 45-56.
https://doi.org/10.1053/j.jrn.2011.12.007
[9]  Martinez Cantarin, M.P., Waldman, S.A., Doria, C., Frank, A.M., Maley, W.R., Ramirez, C.B., Keith, S.W. and Falkner, B. (2013) The Adipose Tissue Production of Adiponectin Is Increased in End-Stage Renal Disease. Kidney International, 83, 487-494.
https://doi.org/10.1038/ki.2012.421
[10]  Ohashi, K., Iwatani, H., Kihara, S., Nakagawa, Y., Komura, N., Fujita, K., Maeda, N., Nishida, M., Katsube, F., Shimomura, I., Ito, T. and Funahashi, T. (2007) Exacerbation of Albuminuria and Renal Fibrosis in Subtotal Renal Ablation Model of Adiponectin-Knockout Mice. Arteriosclerosis Thrombosis and Vascular Biology, 27, 1910-1917.
https://doi.org/10.1161/ATVBAHA.107.147645
[11]  Sharma, K., Ramachandrarao, S., Qiu, G., et al. (2008) Adiponectin Regulates Albuminuria and Podocyte Function in Mice. Journal of Clinical Investigation, 118, 1645-1656.
https://doi.org/10.1172/JCI32691
[12]  Rutkowski, J.M., Wang, Z.V., Park, A.S.D., et al. (2013) Adiponectin Promotes Functional Recovery after Podocyte Ablation. Journal of the American Society of Nephrology, 24, 268-282.
https://doi.org/10.1681/ASN.2012040414
[13]  Yu, Y., Bao, B.J., Fan, Y.P., et al. (2014) Changes of Adiponectin and Its Receptors in Rats Following Chronic Renal Failure. Renal Failure, 36, 92-97.
https://doi.org/10.3109/0886022X.2013.830975
[14]  Christou, G.A. and Kiortsis, D.N. (2014) The Role of Adiponectin in Renal Physiology and Development of Albuminuria. Journal of Endocrinology, 221, R49-R61.
https://doi.org/10.1530/JOE-13-0578
[15]  Kim, H.Y., Bae, E.H., Ma, S.K., Chae, D.W., Choi, K.H., Kim, Y.-S., Hwang, Y.-H., Ahn, C. and Kim, S.W. (2016) Association of Serum Adiponectin Level with Albuminuria in Chronic Kidney Disease Patients. Clinical and Experimental Nephrology, 20, 443-449.
https://doi.org/10.1007/s10157-015-1173-4
[16]  Bulum, T., Vucic Lovrencic, M., Tomic, M., Vu?kovi?-Rebrina, S., Roso, V., Kolari?, B., Vuksan, V. and Duvnjak, L. (2019) Serum Adipocytokines Are Associated with Microalbuminuria in Patients with Type 1 Diabetes and Incipient Chronic Complications. Diabetes Metabolic Syndrome: Clinical Research Reviews, 13, 496-499.
https://doi.org/10.1016/j.dsx.2018.11.001
[17]  Hashikawa-Hobara, N., Chan, Y.K. and Levi, R. (2012) Histamine 3 Receptor Activation Reduces the Expression of Neuronal Angiotensin II Type 1 Receptors in the Heart. Journal of Pharmacology and Experimental Therapeutics, 340, 185-191.
https://doi.org/10.1124/jpet.111.187765
[18]  Hill, N.R., Fatoba, S.T., Oke, J.L., Hirst, J.A., O’Callaghan, C.A., Lasserson, D.S. and Richard Hobbs, F.D. (2016) Global Prevalence of Chronic Kidney Disease—A Systematic Review and Meta-Analysis. PLoS ONE, 11, e0158765.
https://doi.org/10.1371/journal.pone.0158765
[19]  El-Shafey, E.M. and Shalan, M. (2014) Plasma Adiponectin Levels for Prediction of Cardiovascular Risk among Hemodialysis Patients. Therapeutic Apheresis and Dialysis, 18, 185-192.
https://doi.org/10.1111/1744-9987.12065
[20]  Iwashima, Y., Horio, T., Kumada, M., et al. (2006) Adiponectin and Renal Function, and Implication as A Risk of Cardiovascular Disease. American Journal of Cardiology, 98, 1603-1608.
https://doi.org/10.1016/j.amjcard.2006.07.039
[21]  Becker, B., Kronenberg, F., Kielstein, J.T., Haller, H., Morath, C., Ritz, E., Fliser, D. and for the MMKD Study Group (2005) Renal Insulin Resistance Syndrome, Adiponectin and Cardiovascular Events in Patients with Kidney Disease: The Mild and Moderate Kidney Disease Study. Journal of the American Society of Nephrology, 16, 1091-1098.
https://doi.org/10.1681/ASN.2004090742
[22]  Abdallah, E., Waked, E., Nabil, M., et al. (2012) Adiponectin and Cardiovascular Outcomes among Hemodialysis Patients. Kidney Blood Pressure Research, 35, 247-253.
https://doi.org/10.1159/000334649
[23]  Menon, V., Li, L.J., Wang, X.L., Greene, T., et al. (2006) Adiponectin and Mortality in Patients with Chronic Kidney Disease. Journal of the American Society of Nephrology, 17, 2599-2606.
https://doi.org/10.1681/ASN.2006040331
[24]  Von Eynatten, M., Liu, D., Hock, C., et al. (2009) Urinary Adiponectin Excretion: A Novel Marker for Vascular Damage in Type 2 Diabetes. Diabetes, 58, 2093-2099.
https://doi.org/10.2337/db09-0204
[25]  Zhan, J.K., Wang, Y., He, J.Y., Wang, Y.-J., Tan, P., Tang, Z.-Y., Deng, H.-Q., Huang, W. and Liu, Y-S. (2015) Artery Calcification, Osteoporosis, and Plasma Adiponectin Levels Inchinese Elderly. Heart & Lung, 44, 539-543.
https://doi.org/10.1016/j.hrtlng.2015.08.006
[26]  Sakura, T., Okuno, S., Nishio, E., Norimine, K., Ishimura, E., Yamakawa, T., Shoji, S. and Inaba, M. (2017) The Association of Serum Adiponectin with Abdominal Aortic Calcification in Japanese Male Hemodialysis Patients: A Cross-Sectional Observational Study. Scientific Reports, 7, Article No. 6434.
https://doi.org/10.1038/s41598-017-06850-4
[27]  Hyun, Y.Y., Kim, H., Oh, Y.K., Oh, K.-H., Ahn, C., Sung, S.A., Choi, K.H., Kim, S.W. and Lee, K.-B. (2019) High Fibroblast Growth Factor 23 Is Associated with Coronary Calcification in Patients with High Adiponectin: Analysis from the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease Study. Nephrology Dialysis Transplantation, 34, 123-129.
https://doi.org/10.1093/ndt/gfy110
[28]  Lewerin, C., Johansson, H., Lerner, U.H., Karlsson, M.K., Lorentzon, M., Barrett-Connor, E., Smith, U., Ohlsson, C. and Mellstr?m, D. (2015) High Serum Adiponectin Is Associated with Low Blood Haemoglobin in Elderly Men: The Swedish Mros Study. Journal of Internal Medicine, 278, 68-76.
https://doi.org/10.1111/joim.12340
[29]  Kohno, K., Narimatsu, H, Shiono, Y, et al. (2014) Management of Erythropoiesis: Cross-Sectional Study of the Relationships between Erythropoiesis and Nutrition, Physical Features, and Adiponectin in 3519 Japanese People. European Journal of Haematology, 92, 298-307.
https://doi.org/10.1111/ejh.12250
[30]  Kim, H., Yun, H.R., Park, S., et al. (2018) High Serum Adiponectin Is Associated with Anemia Development in Chronic Kidney Disease: The Results from the KNOW-CKD Study. Cytokine, 103, 1-9.
https://doi.org/10.1016/j.cyto.2017.12.018
[31]  Cawthorn, W., Scheller, E., Learman, B., et al. (2014) Bone Marrow Adipose Tissue Is an Endocrine Organ That Contributes to Increased Circulating Adiponectin during Caloric Restriction. Cell Metabolism, 20, 368-375.
https://doi.org/10.1016/j.cmet.2014.06.003
[32]  Moorthi, R.N., Fadel, W., Eckert, G.J., Ponsler-Sipes, K., Moe, S. M. and Lin, C. (2015) Bone Marrow Fat Is Increased in Chronic Kidney Disease by Magnetic Resonance Spectroscopy. Osteoporosis International, 26, 1801-1807.
https://doi.org/10.1007/s00198-015-3064-7
[33]  Hyun, Y.Y., Lee, K.B., Oh, K.H., et al. (2017) Serum Adiponectin and Protein-Energy Wasting in Predialysis Chronic Kidney Disease. Nutrition, 33, 254-260.
https://doi.org/10.1016/j.nut.2016.06.014
[34]  Nagasu, H., Satoh, M., Kiyokage, E., et al. (2016) Activation of Endothelial NAD(P)H Oxidase Accelerates Early Glomerular Injury in Diabetic Mice. Laboratory Investigation, 96, 25-36.
https://doi.org/10.1038/labinvest.2015.128
[35]  Hu, J., Dong, J., Yang, Z., Wu, H. and Yang, N. (2017) Protective Effects of Adiponectin against Diabetic Renal Injury in a Mouse Model of Diabetes. Cellular Physiology and Biochemistry, 43, 870-878.
https://doi.org/10.1159/000481612
[36]  Kacso, I., Lenghel, A., Bondor, C.I., et al. (2012) Low Plasma Adiponectin Levels Predict Increased Urinary Albumin/Creatinine Ratio in Type 2 Diabetes Patients. International Urology and Nephrology , 44, 1151-1157.
https://doi.org/10.1007/s11255-011-0064-1
[37]  Moreno, L.O., Salvemini, L., Mendonca, C., et al. (2015) Serum Adiponectin and Glomerular Filtration Rate in Patients with Type 2 Diabetes. PLoS ONE, 10, e0119529.
https://doi.org/10.1371/journal.pone.0119529
[38]  Panduru, N.M., Saraheimo, M., Forsblom, C., et al. (2015) Urinary Adiponectin Is an Independent Predictor of Progression to End-Stage Renal Disease in Patients with Type 1 Diabetes and Diabetic Nephropathy. Diabetes Care, 38, 883-890.
https://doi.org/10.2337/dc14-2276
[39]  Ha, K.H. and Kim, D.J. (2016) Urinary Adiponectin and Progression of Diabetic Nephropathy in Type 1 Diabetes. Journal of Diabetes Investigation, 7, 470-471.
https://doi.org/10.1111/jdi.12427
[40]  Yamamoto, M., Fujimoto, Y., Hayashi, S., et al. (2018) A Study of High, Middle and Low Molecular Weight Adiponectin in Urine as A Surrogate Marker for Early Diabetic Nephropathy Using Ultrasensitive Immune Complex Transfer Enzyme Immunoassay. Annals of Clinical Biochemistry, 55, 525-534.
https://doi.org/10.1177/0004563217748681
[41]  Balducci, S., Zanuso, S., Nicolucci, A., et al. (2010) Anti-Inflammatory Effect of Exercise Training in Subjects with Type 2 Diabetes and the Metabolic Syndrome Is Dependent on Exercise Modalities and Independent of Weight Loss.Nutrition, Metabolism, and Cardiovascular Diseases: NMCD, 20, 608-617.
https://doi.org/10.1016/j.numecd.2009.04.015
[42]  Navaneethan, S.D., Kelly, K.R., Sabbagh, F., et al. (2010) Urinary Albumin Excretion, HMW Adiponectin, and Insulin Sensitivity in Type 2 Diabetic Patients Undergoing Bariatric Surgery. Obesity Surgery, 20, 308-315.
https://doi.org/10.1007/s11695-009-0026-1
[43]  Yamauchi, T., Iwabu, M., Okada-Iwabu, M., et al. (2014) Adiponectin Receptors: A Review of Their Structure, Function and How They Work. Best Practice Research Clinical Endocrinology Metabolism, 28, 15-23.
https://doi.org/10.1016/j.beem.2013.09.003
[44]  Rojas, E., Rodríguez-Molina, D., Bolli, P., et al. (2014) The Role of Adiponectin in Endothelial Dysfunction and Hypertension. Current Hypertension Reports, 16, Article No. 463.
https://doi.org/10.1007/s11906-014-0463-7
[45]  Kakuda, H., Kobayashi, J., Sakurai, M., et al. (2019) Residual Effect of Sodium Glucose Cotransporter 2 Inhibitor, Tofogliflozin, on Body Weight after Washout in Japanese Men with Type 2 Diabetes. Journal of Clinical Medicine Research, 11, 35-41.
https://doi.org/10.14740/jocmr3650
[46]  Tsunoda, F., Asztalos, I.B., Horvath, K.V., Steiner, G., Schaefer, E.J. and Asztalos, B.F. (2016) Fenofibrate, HDL, and Cardiovascular Disease in Type-2 Diabetes: The DAIS Trial. Atherosclerosis, 247, 35-39.
https://doi.org/10.1016/j.atherosclerosis.2016.01.028

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133