糖尿病足溃疡发病机制研究进展
Progress in the Pathogenesis of Diabetic Foot Ulcer

DOI: 10.12677/BP.2019.94004, PP. 29-35

Keywords: 糖尿病足，伤口愈合，溃疡，发病机制
Diabetic Foot, Wound Healing, Ulcer, Pathogenesis

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Abstract:

正常状况下，伤口愈合是一个动态且复杂的过程，包括凝血，炎症，增殖以及重塑四个阶段，涉及多种细胞、细胞因子、细胞外成分以及生长因子间的相互作用。糖尿病患者由于血糖异常等多种因素，导致伤口愈合的一个或多个阶段受到抑制，因而愈合缓慢，可能发展成为糖尿病足溃疡。同时，糖尿病足溃疡是一种致残性溃疡，患者截肢及死亡率很高。鉴于糖尿病患者伤口愈合的复杂性，本文综述了伤口愈合不同阶段的特点，以及糖尿病伤口愈合的病理生理学机制，为糖尿病足溃疡的治疗提供切入点。
Under normal conditions, wound healing is a dynamic and complex process including hemostasis, inflammation, proliferation, and remodeling, involving a variety of cells, extracellular components, growth factors, and cytokine interactions. In diabetic patients, one or more stages of wound healing are inhibited due to various factors such as abnormal blood glucose, thus wounds heal slowly and may develop into diabetic foot ulcers. Diabetic foot ulcers are a type of disabling ulcer that causes amputation and a high mortality rate. In view of the complexity of wound healing in diabetic patients, this paper summarized the characteristics of different stages of wound healing and the pathophysiological mechanism of wound healing in diabetic patients, so as to provide a starting point for the treatment of diabetic foot ulcer.

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