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HCN通道在突触传递和可塑性中的作用研究进展
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Abstract:
超极化激活环核苷酸门控(HCN)离子通道分布于神经组织中，在不同类型的神经元中表达丰富，在调控细胞膜兴奋性等方面发挥重要作用。HCN通道广泛参与了神经元的突触传递和可塑性变化以及中枢神经系统疾病的病理生理过程。HCN通道已成为慢性疼痛及一些神经系统疾病的潜在治疗靶点。本文将重点围绕HCN通道在突触传递和可塑性中的作用及其调节机制进行综述。
Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels, distributed in nervous tis-sues and highly expressed in different neurons, have important roles in modulating neuronal ex-citability. HCN channels are widely involved in the changes of synaptic transmission and plasticity and pathophysiological process of specific nervous diseases. HCN channels seem to be promising targets for specific nervous diseases as well as chronic pain. In this review, we summarized the roles of HCN channels on the synaptic transmission and plasticity with their regulatory factors.
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