角膜移植术后使用他克莫司滴眼液、环孢素滴眼液对角膜厚度影响的分析
Effects of Tacrolimus and Cyclosporin Eye Drops on Corneal Thickness after Corneal Transplantation

目的：通过比较角膜移植术后使用他克莫司滴眼液与环孢素滴眼液后对中央角膜植片厚度的影响，评价他克莫司滴眼液与环孢素滴眼液对角膜角膜移植术后角膜植片功能的影响。方法：随机从2017年5月~2018年2月之间在昆明市第一人民医院行角膜移植手术的患者中选取38例患者，随机分为2组，A组21名术后使用妥布霉素地塞米松眼液联合他克莫司滴眼液，B组17名使用妥布霉素地塞米松眼液联合环孢素滴眼液，分别于术后1周、术后1月、术后3月、术后6月进行随访，使用前节OCT对术眼中央角膜厚度测量进行测量。使用SPSS 21.0将结果作随机区组设计方差分析。结果：1) 角膜移植术后1周角膜移植患者角膜厚度，他克莫司组平均为530.583 μm，环孢素组为631.545 μm，差异无统计学意义(P > 0.05)，但术后1周开始用眼液，实则无意义；2) 角膜移植术后1月角膜移植患者角膜厚度，他克莫司组平均为529.300 μm，环孢素组为558.500 μm，差异无统计学意义(P > 0.05)；3) 角膜移植术后3月角膜移植患者角膜厚度，他克莫司组平均为532.636 μm，环孢素组为501.500 μm，差异无统计学意义(P > 0.05)；4) 角膜移植术后6月角膜移植患者角膜厚度，他克莫司组平均为559.143 μm，环孢素组为444.625 μm，差异有统计学意义(P < 0.05)。结论：从远期疗效、转归或进展恢复的程度来看，他克莫司眼液对于角膜移植术后角膜厚度的稳定性优于环孢素眼液。
Objective: To evaluate the effect of tacrolimus and cyclosporin on the thickness of central corneal graft after corneal transplantation. Methods: Randomly from May, 2017-February 2018 between the first people’s hospital in the city of Kunming line from 38 cases of corneal transplant patients, randomly divided into 2 groups, group A 21 postoperative use of tobramycin dexamethasone eye drops combined tacrolimus eye drops, group B 17 using tobramycin dexamethasone eye drops joint ring spore eye drops, respectively in postoperative 1 week, 1 month after surgery, postoperative 3 months, 6 months follow-up after surgery, using anterior segment OCT to measure eye central corneal thickness measurement. SPSS 21.0 was used for random block group design an OVA. Results: 1) Corneal thickness was 530.583 m in tacrolimus group and 631.545 m in cyclosporine group 1 week after corneal transplantation, and the difference was not statistically significant (P > 0.05). However, eye fluid was not significant after 1 week after corneal transplantation. 2) Corneal thickness was 529.300 m in tacrolimus group and 558.500 m in cyclosporine group 1 month after corneal transplantation, and the difference was not statistically significant (P > 0.05). 3) Corneal thickness of patients 3 months after corneal transplantation was 532.636 m in tacrolimus group and 501.500 m in cyclosporine group, with no statistically significant difference (P > 0.05). 4) The corneal thickness of the patients 6 months after corneal transplantation was 559.143 m in tacrolimus group and 444.625 m in cyclosporine group, with statistically significant differences (P < 0.05). Conclusion: Tacrolimus solution is more stable than cyclosporine solution for corneal thickness after corneal transplantation.