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硫辛酸的抗氧化作用及其临床某些应用
Antioxidation of Lipoic Acid and Its Clinical Application

DOI: 10.12677/CC.2020.43003, PP. 21-25

Keywords: 硫辛酸，抗氧化剂，氧化应激，氧化损伤
Lipoic Acid, Antioxidants, Oxidative Stress, Oxidative Damage

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Abstract:

硫辛酸是已知抗氧剂中抗氧化能力最强的抗氧化剂，因其具有良好的脂溶性和水溶性在体内外均能发挥抗氧化作用。研究发现，糖尿病及糖尿病并发症、神经退行性疾病、心脑血管疾病等可能与体内氧化应激有关，硫辛酸的双硫五元环结构决定其具备抗氧化、抗炎能力，能有效清除大部分自由基，减低氧化损伤保护内皮细胞。目前，在临床应用上具有很强的优势。
Lipoic acid is known to be the strongest antioxidant among antioxidants. Its good lipid solubility and water solubility in vivo and in vitro can play an antioxidant role. Studies have found that diabetes mellitus and its complications, neurodegenerative diseases cardiovascular and cerebrovascular diseases, etc. may be related to oxidative stress in vivo. The disulfide pentagonal ring structure of lipoic acid determines its antioxidant and anti-inflammatory abilities, effectively scavenging most free radicals, and reducing oxidative damage. It has a broad prospect in clinical application.

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