全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...
-  2019 

Fast

DOI: 10.1177/1535759719835351

Full-Text   Cite this paper   Add to My Lib

Abstract:

Perineuronal Nets Decrease Membrane Capacitance of Peritumoral Fast Spiking Interneurons in a Model of Epilepsy Tewari BP, Chaunsali L, Campbell SL, Patel DC, Goode AE, and Sontheimer H. Nat Commun. 2018;9(1):4724. Patients with brain tumor commonly present with epileptic seizures. We show that tumor-associated seizures are the consequence of impaired GABAergic inhibition due to an overall loss of peritumoral fast-spiking interneurons (FSNs) concomitant with a significantly reduced firing rate of those that remain. The reduced firing is due to the degradation of perineuronal nets (PNNs) that surround FSNs. We show that PNNs decrease specific membrane capacitance of FSNs permitting them to fire action potentials at supraphysiological frequencies. Tumor-released proteolytic enzymes degrade PNNs, resulting in increased membrane capacitance, reduced firing, and hence decreased GABA release. These studies uncovered a hitherto unknown role of PNNs as an electrostatic insulator that reduces specific membrane capacitance, functionally akin to myelin sheaths around axons, thereby permitting FSNs to exceed physiological firing rates. Disruption of PNNs may similarly account for excitation-inhibition imbalances in other forms of epilepsy and PNN protection through proteolytic inhibition may provide therapeutic benefits.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133