Immediate Vitrectomy Following Inadvertent Intravitreal Injection of Depo

To report a case of an iatrogenic intraocular injection of Depo-Medrol where prompt vitrectomy was performed leading to a good visual and anatomical outcome. Retrospective case report and review of the literature. A 61-year-old man received an injection of Depo-Medrol for the treatment of trigeminal neuralgia that was inadvertently injected into the globe of the left eye leading to sudden and severe vision loss. Prompt vitrectomy was performed within 4 hours. Electroretinogram revealed that b-wave amplitudes in scotopic and photopic conditions were decreased by 25%. Following subsequent cataract surgery, the patient’s visual acuity improved to 20/20 vision. The toxic effects of Depo-Medrol may be dependent on the temporal and spatial contact of the preservative with the retina where prolonged exposure may cause widespread retinal damage hindering visual rehabilitation. Immediate vitrectomy may be crucial to preserve the anatomy and function of the retina