Acute

Endophthalmitis in postoperative silicone oil–filled eyes is rare. The traditional management of these eyes is a return to the operating room for oil removal, instillation of intravitreal antibiotics, and reinjection of silicone oil. We describe 2 cases of endophthalmitis successfully treated with an office injection of intravitreal antibiotics. In both eyes, there was a prompt resolution of endophthalmitis with no apparent signs of retinal toxicity and with favorable visual outcomes. These are the first cases to be described of endophthalmitis in silicone oil–filled eyes successfully treated with intravitreal antibiotics alone