The role of sexual risk behaviors on PrEP awareness and interest among men who have sex with men in Latin America

In Latin America, men who have sex with men (MSM) remain disproportionately impacted by HIV. Pre-exposure prophylaxis (PrEP) is an effective HIV prevention tool and has been FDA approved in the United States since 2012, but no Latin American state, with the recent exception of Brazil, has implemented PrEP guidelines. We carried out a multinational online survey of MSM in Latin America (n？=？22698) in 2012 to assess whether MSM at highest risk of HIV acquisition (i.e., those engaging in condomless anal sex [CAS; n？=？2606] and transactional sex [n？=？1488]) had higher levels of awareness of PrEP, PrEP use and interest in participating in a PrEP trial. After adjusting for demographic and psychosocial characteristics including depressive symptoms, hazardous alcohol use, childhood sexual abuse, and sexual compulsivity, transactional sex and CAS were associated with increased PrEP awareness (aOR？=？1.29, 95% CI: 1.05–1.59, p？<？.001 and aOR？=？1.22, 95% CI: 1.11–1.34, p？<？.001, respectively) and PrEP trial interest (aOR？=？1.45, 95% CI: 1.25–1.71, p？<？.001 and aOR？=？1.74, 95% CI: 1.57–1.95, p？<？.001, respectively). Findings demonstrate substantial awareness of and interest in PrEP among MSM with behavioral risk factors for HIV in Latin America, suggesting that this region is primed for PrEP implementation, which has been slow