Long

Introduction: We investigated the stability of effects of a computerized cognitive training previously administered to a large group of early stage Alzheimer’s disease (AD) patients, as compared with a control group. Method: Eighty AD patients were randomized in two groups and underwent a computerized cognitive training, or a control intervention. Results: A Repeated Measures General Linear Model (RM-GLM) showed a significant interaction effect for the following neuropsychological tests: the digit span forward and backward, and the two-syllable words test, as measures of short-term memory and working memory; the Rivermead Behavioural Memory Test (RBMT) story immediate and the RBMT story delayed, as measures of ecologically oriented memory; the Token test, as measure of language comprehension; and the Brixton test, as an executive functions measure. Conclusion: Patients in the experimental group showed a significant improvement in various neuropsychological domains due to the training, and these effects decreased after 12 months