Mechanistic Science: A New Approach to Comprehensive Psychopathology Research That Relates Psychological and Biological Phenomena

Efforts to understand the causes of psychopathology have remained stifled in part because current practices do not clearly describe how psychological constructs differ from biological phenomena and how to integrate them in unified explanations. The present article extends recent work in philosophy of science by proposing a framework called mechanistic science as a promising way forward. This approach maintains that integrating psychological and biological phenomena involves demonstrating how psychological functions are implemented in biological structures. Successful early attempts to advance mechanistic explanations of psychological phenomena are reviewed, and lessons are derived to show how the framework can be applied to a range of clinical psychological phenomena, including gene by environment findings, computational models of reward processing in schizophrenia, and self-related processes in personality pathology. Pursuing a mechanistic approach can ultimately facilitate more productive and successful collaborations across a range of disciplines