Evaluation of Risk Factors of Progressing IgA Nephropathy in Children

Clinical and morphological changes in the IgA nephropathy in children to determine high risk patients for disease progression. Our research included 29 patients at age <17. During framework of the research therapy of the IgA nephropathy included prednisolone, azathioprine and dipyridamole, length of the therapy was 24 months. Kidney biopsy was performed to the all patients which revealed IgA nephropathy in >80% glomeruli with mesangial proliferation. In our research in children with IgA nephropathy 24 hour protein excretion and frequency of glomeruli with crescents were independent risk factors of permanent proteinuria by the end of 2 years combined therapy. Combined therapy of children with severe IgA nephropathy showed good efficiency, but it can be less effective for children with 24 hour urine excretion >1,32g/1,73m² or crescents in the biopsy in more than 14% glomeruli