Informatively of the Indicators of Blood Allowing to Predict Premature Water Breaking at Prematurely Born Pregnancy

The study of the relationship in 47 pregnant women with premature outflow of amniotic fluid of coagulation hemostasis, pro-inflammatory cytokines, complement C3, C4 fractions and insulin-like growth factor-1 in blood serum revealed activation of the prothrombinase internal mechanism of formation, which under conditions of premature outflow of water, due to which local outflow occurs and systemic activation of antigen-stimulated macrophages, NK cells, lymphocytes, neutrophils and activation of the complement system. Determination of serum levels of TIF –a, IL-1β, C3-, C4-complement fractions in pregnant women with ROM can be used to predict the development and timely correction of changes in blood coagulation potential, which will expand the possibilities of successfully choosing an adequate treatment tactic and timely warning development of complications during pregnancy