Coordination Complexes of Transition Metals and Schiff Base with Potent Medicinal Activity

The ligand N,N'-bis(salicylidene)ethylenediamine has been synthesized from the condensation of salicylaldehyde with ethylenediamine and, after isolation in the solid forms, it has been complexed with Ni (II) and Zn (II) ions. During the complexation reaction with transition metal ions, the four dentate ligand is coordinated with the central metal atom by its two active donor atoms N and O and from ¹H NMR, it is also established that C-H is activated with Ni (II) ions. The structures of the complexes have been elucidated by IR, ¹H NMR and a combination of other analytical and physical measurements. UV-Visible spectrophotometer has been used to detect metals and specific absorption has been found for each metal. Some gram-negative bacteria such as E. Coli, Shigella Dysenteriae and Shigella Sonnei have been tested with metal complexes and a significant inhibition of bacterial growth by the metal complexes has been noted. To understand the antibacterial activity of these metal complexes streptomycin and ciprofloxacin have been used as standards during the experiment