Thyroid Cells Development under Thyreostatic Burdon

Today thyroid gland pathologies take one of the leading places among endocrine disorders. Factors such as unfavorable ecology, change of environmental micro element composition, hereditary predisposition play a certain role in the development of thyroid pathology. Morphology of thyroid tissue, which is well known reliably reflects the degree of thyroid functional activity in various physiological and pathological conditions of an organism, in fact is not studied in various stages of experimental hypothyroids early postnatal ontogenesis. Merkazolil is one of the thyreostatics that block pyroxide oxidase, participating in the synthesis of thyroid hormones of thyroid gland, which prevents the iodization process. The active part of the drug enters the thyroid gland tissue which formed a stable compound with hydrogen peroxide, as a result of which the enzymatic function catalyzes the iodine compound. The synthesis of thyroid hormones in the beginning decreases, and follicular contents increase in the future. A-cells-thyrocytesthat are lined on the wall of the follicle of the gland, B-cells are found in the parenchyma of the gland were first described in 1898 year were found in nodular goiter, adenomas and some thyroid diseases. C-cells are calcitoninocytes that produce the parathyroid hormone antagonist of calcitonin. It is necessary to find out the effect of mercazolil on the functional morphology of the thyroid gland in laboratory rats undergoing hypothyroidism, and also to establish the significance of the changes undergoing in the growing organism in the formation of structural damage to the organ