Tissue Factor and Platelet Microparticles in Acute Myocardial Infarction

Aim of the work: This study aimed to assess the presence of tissue factor and platelet microparticles in cases of acute myocardial infarction in relation to clinical outcome. Patients and methods: This study included 42 patients with acute ST elevation Myocardial infarction. The counting of platelet microparticles carrying CD42b&CD42b (MFI and tissue factor microparticles carrying CD142&CD142 (MFI) was done by flow cytometry. Systemic blood samples of 40 healthy individuals (control) were obtained to assay the studied parameters. A comparison was done between the patients according to their clinical picture and mode of treatment used, and also between patients and control cases. Results: There was high statistical significant elevation of platelet microparticles (count and MFI) and tissue factor microparticles (count and MFI) in patients group in comparison with the control group. There was no statistically significant difference between patients on medical treatment and patients receiving no treatment as regard platelet microparticles and tissue factor microparticles. The study shows highly statistically significant difference between patients without and with primary PCI as regard platelet microparticles and tissue factor microparticles. The study also shows high significant positive correlation between platelet microparticles CD42b (MFI) and tissue factor microparticles CD142 (MFI), and shows non-significant correlation between platelet microparticles CD42b (MFI) and other parameters in control group