Body Systemic Response to Optimize Reparative Bone Regeneration

Reparative regeneration of bone tissue and its optimization is a topical problem in both clinical and fundamental science. It can be performed with the help of local and systemic factors [A.S. Avrunin et al. 2018; A.S. Grioryan et al. 2015; Y.M. Iryanov, 2012; I.V. Mayborodin et al. 2015; G.A. Onoprienko, V.P. Voloshin, 2017; I.DuniS-Cule et al. 2014; W.Li et al. 2015]. They have a significant impact on angiogenesis, differentiation of osteoblasts and osteoclasts, osteogistogenesis [O.L. Grebneva et al., 2012; M.V. Stogov, 2013; A.M.Ali, 2015; Y.H.Kim et al., 2015; W.Li et al., 2015; N.Oxata et al., 2015; V.Shi et al., 2015, etc.]. ] The overwhelming number of works devoted to the improvement of treatment results is based on a mechanical approach based on the need for comparison of fragments and reliable fixation [G.V. Dyachkova et al., 2018, etc.]. However, according to researchers, the restoration of blood supply and metabolism, correction of neuroimmune endocrine relationships is no less critical K.V. Sudakov et al., 2010; L.B. Reznik et al., 2015; W.Li et al., 2015; V.Shi et al., 2015, etc.]