Association of Polymorphic Markers of Leu28Pro Gene APOE and T-786C Gene ENOS3 in Diabetic Nephropathy in Uzbek Nation

The aim of the present study was to determine the association of association of the Leu28Pro polymorphic markers of the APOE gene, T-786C of the NOS3 gene with the development of diabetic nephropathy, 129 patients with type 2 diabetes were examined. Patients in the main group: 65 patients with a disease duration of up to 10 years, without diabetic nephropathy (33 patients) and with diabetic nephropathy (32 patients), 64 patients with diabetes lasting more than 10-20 years, with no diabetic nephropathy (31 patients) and diabetic nephropathy (33 patients). Genotyping was carried out by polymerase chain reaction. The study showed the association of the Pro allele and the Leu/Pro genotype of the APOE gene and the C allele and the CC genotype of the NOS3 gene with a risk of developing diabetic nephropathy in patients with type 2 diabetes mellitus in the studied Uzbek nation