Ampullary and pancreatic adenocarcinoma—a comparative study

Pancreatic ductal adenocarcinoma (PDAC) and ampullary adenocarcinoma (AAC) are 2 gastrointestinal cancers that share overlapping symptoms (1). Although some studies have proposed the hypothesis of their differences in pathogenesis, prognosis and molecular profile; they remain treated similarly by pancreaticoduodenectomy followed by adjuvant chemotherapy (2,3)