Relationship between NAMPT/PBEF/visfatin and prognosis of patients with malignant tumors: a systematic review and meta-analysis

As the most concerned health topic worldwide, cancer has been reported to be one of the main life limiting factors in the UK countries (1), the secondary life-threatening factor in the United States (2) and the first cause of death in China (3). In both developed and developing countries, it has also been an important burden restricting the social and economic development (4). At present, medical workers and researchers around the world are dedicating their lives to improve the quality of life in patients with malignant tumors and to prolong their survival time. However, the prognoses of many cancer patients remain poor. Hence, there is an urgent need to explore the possible mechanism affecting the prognosis of these patients