Chemoradiotherapy versus chemotherapy alone for unresected intrahepatic cholangiocarcinoma: practice patterns and outcomes from the national cancer data base

Despite its rarity in the United States, intrahepatic cholangiocarcinoma (IC) is associated with a poor prognosis, especially for unresected disease. The National Comprehensive Cancer Network (NCCN) offers a category 1 recommendation of chemotherapy (CT) alone for this population (1). Chemoradiotherapy (CRT) is a category 2a recommendation, largely owing to no randomized evidence to date