Advance modern medicine with clinical case reports

The evidence-based health care places randomized clinical trial (RCT) at the top of the hierarchy for clinical evidence, while case reports are at the bottom (1,2). RCT is meant for the evaluation of medical interventions in which there is uncertainty about a benefit that is in itself not striking. RCT is costly and time intensive, often limit scientists and clinicians to examining a few limited variables, and can fail to demonstrate the richness of individual patient characteristics. Given the unpredictable nature of medicine, a patient may present in an unusual way, have a strange new pathology, or react to a medical intervention in a manner not seen before. The publication of these novelties as case reports is a fundamental way of conveying medical knowledge. Throughout history there have been famous case studies that shaped the way we view health and disease