The JAK2/STAT3 pathway is involved in dexmedetomidine-induced myocardial protection in rats undergoing cardiopulmonary bypass

Cardiopulmonary bypass (CPB) is an essential technique in cardiovascular surgery. However, during CPB, the myocardium may be harmed by cardiac ischemia-reperfusion injury, oxidative stress injury, and CPB-related systemic inflammatory response (1). Severe myocardial injury after cardiovascular surgery results in heart failure, slowing the recovery of patients and increasing hospitalization costs. Several attempts have been made to develop procedures for myocardial protection against CPB-related injury in cardiovascular surgery, such as remote ischemic preconditioning (2), modified cardioplegia (3), and drug intervention (4)