Efficacy of granisetron and aprepitant in a patient who failed ondansetron in the prophylaxis of radiation induced nausea and vomiting: a case report

Radiation therapy is an effective method of relieving pain caused by bone metastases (BM) and can significantly improve functional ability and decrease the need for analgesic use. While radiation therapy is an effective tool for relieving pain, it may also induce emesis in certain patients who receive it to more sensitive areas (1). Radiotherapy-induced nausea and vomiting (RINV) can severely debilitate a patient during and after treatment, which can lead to a decrease in quality of life (QOL) (1-3). RINV may also impact a patient’s ability to complete (4) or desire to accept further treatment, which may have undesirable disease outcomes and additional associated costs (1,3). Therefore, it is essential that RINV is prevented in order to avoid further compromise on QOL, functional abilities, and psychological status in palliative cancer patients (1-3)