Optic nerve head perfusion in normal eyes and eyes with glaucoma using optical coherence tomography-based microangiography

Vascular dysfunction in the optic nerve head (ONH) is thought to be a contributing factor in the development of glaucoma (1,2). Previous studies have shown that glaucomatous eyes have a significant reduction in ocular perfusion compared to normal subjects (3,4). Furthermore, glaucomatous eyes with disease progression have a more pronounced blood flow reduction than eyes without disease progression (3-6). Vascular dysfunction has been observed even before the development of glaucomatous optic neuropathy (2). This evidence supports the association of vascular dysfunction and glaucoma, but its study in the clinical setting has been limited due to a lack of objective measures to quantify ONH perfusion