The genetic contribution of HLA-E*01:03 and HLA-E*01:03-G*01:01 to Posner-Schlossman syndrome in southern Chinese

Posner-Schlossman syndrome (PSS), also known as a glaucomatocyclitic crisis, was first reported by Posner and Schlossman in 1948 (1). PSS is a secondary glaucoma, which occurs in young adults. PSS is a self-limiting and recurrent eye disorder, and 24.3% of patients have more than 2 episodes per year, up to 12 episodes in some cases (2). The main clinical manifestations of PSS are the elevated intraocular pressure (IOP) in one eye with keratic precipitates (KPs). Normally, symptoms in most patients can be relieved by using IOP-reducing and anti-inflammatory drugs, but many studies have shown that PSS is not a completely benign disease (3). Long-term recurrent PSS can lead to optic nerve damage and a reduced number of corneal endothelial cells. Permanent visual impairment can develop in severe cases. Anti-glaucoma surgery is needed in some patients with PSS because of inadequate disease control (3,4)