Radiotherapy and radioembolization for liver metastases

Liver involvement is common in the setting of metastatic cancer, with disease frequently originating from gastrointestinal (GI) sites and spreading via portal venous drainage, but also commonly from lung, breast, and other primary locations. Liver metastases can, depending on location and size, cause significant pain or obstructive symptoms requiring palliative intervention (1). Beyond strict palliation, select patients, namely those with colorectal primary tumors can benefit from aggressive liver-directed therapy with 5-year survival reported at 30-55% in surgical series (2-5)