Safety evaluation of a potential ablation agent—hydrochloric acid in the rabbits’ model

In previous report, it had confirmed that hydrochloric acid (HCl) was an effective ablation agent with single using or combing with radiofrequency ablation. This article systematically evaluated the safety of HCl for the first time. In this study, we found that HCl can cause some changes in arterial blood gas status, hematology and hepatic and renal functions. However, these changes were tolerant and temporary. In imaging and histopathological studies, the lesion caused by HCl was limited. What is more important was that 10% and 20% HCl are more controllable than 30% HCl