MicroRNA-142-3p inhibits IFN-γ production via targeting of RICTOR in Aspergillus fumigatus activated CD4 + T cells

Invasive aspergillosis is one of the most severe pulmonary infections that provokes aspergillosis in patients with compromised immunity, and an associated heightened mortality rate of 50–95%, indicating a relatively poor outcome from the clinical management of this disease (1,2). Aspergillus fumigatus (AFE), identified as an opportunistic fungal pathogen that is quite abundant in external environments, is the main pathogenic fungus of invasive aspergillosis. It has been reported that AFE not only induces fungal infection in immune suppressed individuals but also exacerbates the inflammatory response to invasive aspergillosis