Targeting ticagrelor: a novel therapy for emergency reversal

Potent P2Y12 inhibitors, prasugrel and ticagrelor, are routinely being prescribed in place of clopidogrel for patients with acute coronary syndrome (ACS) due to established superior efficacy in ACS with or without percutaneous coronary intervention (1-3). More potent platelet inhibition translates into an increased risk of bleeding. However, a net clinical benefit favors the use of these agents and has been incorporated in numerous guidelines (4-6)