Identification of molecular subtypes and significantly mutated genes in gastric cancer using next-generation sequencing

Gastric cancer is a complex disease that is caused by interactions among multiple genetic and extrinsic factors. The heterogeneous characteristics of gastric cancer make it difficult to select suitable treatment options for individual patients. According to a clinicopathologic perspective, gastric cancer is divided into two subtypes, intestinal or diffuse, which is also known as Lauren’s classification. This classification helps to understand the pathogenesis of gastric cancer, but it is insufficient as a predictor of disease prognosis and drug treatment. Thus, more elaborate subgrouping of individual patients is required to develop a personalized therapeutic regimen