Real world treatment patterns in the neurogenic bladder population: a systematic literature review

Micturition involves passive, low pressure filling of the bladder during the urine storage phase whilst voiding requires coordination of detrusor contraction with urinary sphincter relaxation. The process is controlled by a complex neural control system, involving interaction between the sympathetic, parasympathetic and somatic nervous systems (1). Disturbance to the normal micturition process as a result of neurological damage or disease is known as neurogenic bladder (NGB). The term NGB encompasses a breadth of neurological etiologies including spina bifida, stroke, spinal cord injuries (SCI), multiple sclerosis (MS), and Parkinson’s disease (PD) (2). Although patients share the same diagnosis of NGB, they are notably unique in urological symptom and risk profile due to the difference in underlying condition (including stage and severity of disease) and location of neurological lesion