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-  2019 

Toward precision medicine based on the molecular landscape of carcinoma in situ of the bronchus: is it realistic for patients with pre-invasive lung disease?

DOI: 10.21037/jtd.2019.04.87

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Abstract:

Early detection of cancer, particularly through screening of high-risk patients, is essential to decreasing the mortality due to cancer, notably lung cancer (1). Early detection is made possible by sampling of cytological and/or histological specimens that provide a diagnosis of the precancerous lesion. The diagnosis of precancerous lesions, in particular those of the lungs, is presently performed using a morphological approach. So, it is the pathologist who identifies and classifies through its microscope low, moderate or severe dysplastic lesions as well as carcinoma in situ of the respiratory epithelium (2-5). Moreover, the detection and clinical surveillance of suspicious macroscopic lesions can be performed using high resolution diagnostic techniques such as autofluorescence bronchoscopy (6-8)

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