A lower level of forced expiratory volume in one second predicts the poor prognosis of small cell lung cancer

Small cell lung cancer (SCLC) accounts for 10–15% of all lung cancers, although the incidence of SCLC has been declining with the decreasing prevalence of smoking (1). SCLC is distinct from non-small cell lung cancer (NSCLC) by its aggressive and rapid-growing features (2). Despite its dramatic initial response to chemotherapy and radiation, SCLC remains associated with poor long-term clinical outcomes. Many putative prognostic factors have been suggested, and the most important factors are poor performance status, weight loss and staging of extensive disease (ED) (3). According to Paesmans et al., age and gender are also independent prognostic factors in SCLC (4)