Meta-analysis of the efficacy and safety of adding an angiotensin receptor blocker (ARB) to a calcium channel blocker (CCB) following ineffective CCB monotherapy

Hypertension is a major risk factor for cardiovascular morbidity and mortality (1-4) and accounts for 13.5% of all-cause mortality worldwide. Strict blood pressure control, as recommended by professional guidelines, significantly reduces the risk of cardiovascular events, stroke and death (5,6). However, at present, the percentage of hypertensive patient achieving recommended targets is below 35% (7)