Hydrogen gas inhalation ameliorates lung injury after hemorrhagic shock and resuscitation

Post-traumatic hemorrhagic shock is the second highest cause of early death (1-3). Therefore, to reduce early mortality from post-traumatic shock, aggressive treatments, such as resuscitation, should be considered. However, there have been reports suggesting that the extent of tissue damage from ischemic-reperfusion injury due to hemorrhagic shock may be exacerbated when oxygen is reintroduced into the tissue after resuscitation (4). In other words, hemorrhagic shock and resuscitation (HSR), which are commonly observed in trauma patients, may cause inflammatory reactions in the lung parenchyma, including various organs, as well as acute lung injury, which may be triggered by HSR, and increase complications of trauma patients that can ultimately lead to death (5,6)