The expression and prognostic value of hypoxia-inducible factor- 1α and p53 in non-small cell lung carcinoma

Lung cancer is the most common malignancy and leading cause of cancer-related death worldwide (1). Non-small cell lung carcinoma (NSCLC) accounts for 75–85% of all lung cancer cases. Despite great advances in diagnosis and therapy, the 5-year survival rate of lung cancer patients remains poor and was reported to be approximately 17% (2). Tumor relapse and metastasis are the main causes of mortality. Several molecular markers have been demonstrated in the literature that are closely related to tumor oncogenesis and progression. Therefore, the detection and analysis of the molecular markers may provide predictive information for the prognosis and may help to optimize treatment strategies