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-  2018 

IQGAP1 plays an important role in the tumorigenesis and invasion of papillary thyroid cancer

DOI: 10.21037/23594

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Abstract:

Papillary thyroid cancer (PTC) is the most common type of thyroid malignancy, accounting for more than 80% of all cases of thyroid cancer. Moreover, the incidence of PTC has increased dramatically over the past several decades (1,2). Several genetic factors are involved in the development of PTC, including the activation of the MAPK signaling pathway as a result of a point mutation within BRAF, RAS mutation or RET/PTC rearrangement (3). Non-coding RNA (ncRNA), including small ncRNA and long ncRNA (lncRNA) has been revealed to be associated with the development of thyroid cancers. A number of studies have discussed the potential uses of ncRNA in the diagnosis and prognosis of thyroid tumors (4). Treatment for PTC with surgery in combination with radioiodine therapy is highly effective. Despite its relatively good prognosis with a 10-year cancer-specific survival rate above 90%, locoregional recurrences and distant metastasis still occur frequently (5). Accurate diagnosis of lymph metastasis and prediction of PTC recurrences is necessary to minimize poor outcomes

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