Human papillomavirus related anal squamous cell carcinoma survival: a systematic review and meta-analysis

Anal squamous cell carcinoma (ASCC) is an uncommon malignancy of the anal canal and perianal skin area, with annual incidences ranging from 1.0 to 2.5 per 100,000 population in many western countries (1). Its incidence is increasing by approximately 2% yearly, particularly in females (2,3)