JMJD3 histone demethylase—a potential therapeutic target for metastatic hepatocellular carcinoma?

Hepatocellular carcinoma (HCC) remains as a top cause of cancer death worldwide. One of challenges in the history of finding ways to eradicate HCC is its complicated pathobiology and its high potential of metastasis, which is not fully understood in terms of mechanisms. Particularly, the mechanism by which metastasis is associated with the hallmarks of cancer, such as aberrant epigenetics modification and genome instability, is still far from clear. The link among all these malignant behaviors and the root of cancer recurrence, the cancer stemness, is even more unclear