The role of lncRNA LSAT1 in the invasion and metastasis of non-small cell lung cancer under hypoxia

The invasion and metastasis of non-small cell lung cancer (NSCLC) has become a key problem which affects the efficacy and long-term survival of patients. Previous studies about the invasion and metastasis of tumors are often confined to the change of internal factors of tumor cells, but ignore the interaction between tumor cells and tumor microenvironment. It is worth mentioning that as the important microenvironment for promoting the development of solid tumors, hypoxia has been verified to affect multiple malignant phenotypes, including invasion and metastasis (1-4). In recent years, long non-coding RNA (lncRNA) has gained more and more attention as a hot point in cancer research. lncRNA is a kind of non-coding RNA with the length of 200 nt. Compared with protein-coding genes, it has obvious specificity of advanced stage and tissue (5,6). The role and mechanism of lncRNA are various and one of the important points is that it can regulate the expression of protein-coding genes on multiple levels (7,8). Furthermore, a lot of researches have confirmed that lncRNA is of a vital importance in the invasion and metastasis of various tumors (9-11)