Screening key lncRNAs and mRNAs for left-sided and right-sided colon adenocarcinoma based on lncRNA-mRNA functional synergistic network

Colon cancer is the fourth most malignant tumor worldwide and the fifth leading cause of cancer-related death (1). A growing body of studies suggests that right-sided colon adenocarcinoma (RSCOAD) and left-sided colon adenocarcinoma (LSCOAD) should be recognized as two distinct categories of cancer (2,3). Recently, the differences between RSCOAD and LSCOAD have attracted people’s attention due to their different outcomes, prognoses, and clinical responses to chemotherapy (2). Primary tumor location associates with survival in patients with metastatic COAD (4). Therefore, it has become an urgent tissue to find the key molecular markers of RSCOAD and LSCOAD