Chemotherapy for breast cancer progresses to liver metastases after surgery and systemic treatment

Approximately 50% of patients with metastatic breast cancer will have liver involvement at some point during the course of their disease, and 5–12% of patients with metastatic breast cancer will have liver involvement (1-3). In these patients, unresectable breast cancer liver metastasis (UBCLM) is a major cause of mortality, and this is associated with poor prognosis. Breast cancer is the second leading cause of cancer-related death among women in the United States, with an estimated 39,840 deaths from breast cancer in 2010 (4)