High expression of TOP2A gene predicted poor prognosis of hepatocellular carcinoma after radical hepatectomy

Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide and one of the leading causes of cancer-related death (1). Nearly 70% of these cancer deaths occur in low and middle-income countries. In recent years, the main treatment methods for HCC include surgical resection, local ablation, transhepatic arterial chemotherapy and embolization (TACE), and molecular targeting (2). However, the therapeutic effects are still not satisfactory. In particular, the recurrence of HCC after surgical resection is a key factor affecting the therapeutic effect, and progress has been slowing for many years (3). Clinical prognostic indexes of primary HCC include tumor size, liver cirrhosis, the grade of tumor differentiation, and invasion of microvessels (4-6). Due to the uncertainty in the development of HCC, the above predictors are still not accurate for predicting the prognosis after surgical resection