Helicase lymphoid-specifics and selenoprotein P1 are potential candidate genes in the progression and prognosis of lung adenocarcinoma

At present, lung cancer remains to be one of the most common malignant tumors and leads to increasing mortality around the world (1,2). During the past decades, the occurrence and mortality of lung cancer are rising rapidly worldwide, especially in those countries with advanced industry (3). Lung adenocarcinoma (AD) is the main histologic subtype of lung carcinoma (4). Although numerous studies verify multiple oncogenes participating in the pathogenesis of lung cancer, the overall 5-year survival rate of lung patients is still very lower (4,5). Thus, identification of molecular mechanisms and pathways for the development of lung tumors will benefit to the therapeutic effect and improve the outcomes of lung AD patients