Clinicopathological characteristics with EGFR, ALK, ROS1 genetic alternation and prognostic analysis of primary lymphoepithelioma-like carcinoma

Lymphoepithelioma-like carcinoma (LELC) is a rare type of lung cancer, which was firstly reported in 1987, when Bégin et al. detected the Epstein-Barr virus (EBV) in a 40-year-old female, nonsmoker of South-East Asiatic origin (1). While LELC contains only 1.15% to 5.90% of lung cancers (2,3), and less than 300 patients were reported in the past three years, details associated with this uncommon type require more description