LncRNA CRNDE modulates cardiac progenitor cells’ proliferation and migration via the miR-181a/LYRM1 axis in hypoxia

Myocardial infarction is a severe cardiovascular disease and a significant risk to human life (1). It could cause heart failure and malignant arrhythmia with high morbidities and mortalities (2). Inflammatory responses and cardiomyocyte apoptosis are the most significant outcomes from myocardial infarction (3). Cell apoptosis of cardiomyocytes after myocardial infarction usually causes ventricular remodeling as well as heart failure (4). In this research, we will be focused to explore the mechanisms for cardiac progenitor cell reproduction in myocardial infarction related heart failure