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-  2018 

Risk factors and methylenetetrahydrofolate reductase gene in congenital heart disease

DOI: 10.21037/jtd.2017.12.08

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Abstract:

Congenital heart disease (CHD) is one of the most common birth defects, with an incidence of 28 per 100 congenital defects in China (1). CHD involves malformation of the cardiovascular system during the embryo stage (2). CHD is a multifactorial disease; its etiology is not fully understood. The occurrence of CHD might be affected by both genetic factors and environmental factors (3). Polymorphisms in genes associated with one-carbon metabolism are risk factors for heart disease (4). The methylenetetrahydrofolate reductase (MTHFR) gene 677 C>T variant is the best-characterized polymorphism in this regard, and this gene has become a research hotspot for understanding genetic susceptibility factors for CHD. Additionally, a variety of potential environmental risk factors, such as parental age, race, occupation and exposure to chemical agents, have been proposed (5-7). Gender prevalence has been completed in CHD children (8). However, few studies have reported on interactions between genetic factors and environmental factors in CHD (9)

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